Eutectic Mixture of Fenofibric Acid and Syringic Acid: Improvement of Dissolution Rate and Its Antihyperlipidemic Activity

Fenofibric acid is a poorly water-soluble drug with high
permeability; thus, it is classified as a Biopharmaceutical
Classification System (BCS) class II. This study aimed to prepare
a eutectic mixture of fenofibric acid with syringic acid as a
coformer to improve its solubility, dissolution rate, and
antihyperlipidemic activity. The solvent co-evaporation method
was used to form a eutectic mixture. Solid-state properties
were characterized, solubility and in vitro dissolution profiles
were studied, and in vivo antihyperlipidemic effectiveness was
investigated in male Wistar rats. The results showed that the
eutectic mixture of fenofibric acid-syringic acid enhanced the
solubility (3.4-fold) and in vitro dissolution rate (3.62-fold) and
significantly improved the antihyperlipidemic activity com�pared with intact fenofibric acid